Hub · Substances
Substance reference
Plain-language, educational substance pages. What each substance is, the analytes drug tests target, panels that include it, and common cross-reactivity notes. No dosing, no sourcing, no use instructions.
THC (cannabis / marijuana)
THC is the principal psychoactive cannabinoid in cannabis. In workplace and clinical screening, the marker is THC-COOH (an inactive metabolite) — not THC itself
stimulantCocaine
Cocaine is a short-acting stimulant. Workplace and clinical assays detect its primary metabolite, benzoylecgonine, which is highly specific and rarely subject t
opioidOpioids (opiates)
The federal panel's opiates assay targets morphine, codeine, and 6-acetylmorphine (a heroin-specific marker). Semi-synthetic opioids like oxycodone and hydrocod
stimulantAmphetamines & methamphetamine
The amphetamines class on the federal panel covers amphetamine, methamphetamine, MDMA and MDA. Immunoassay screens have a high false-positive rate; confirmation
dissociativePCP (phencyclidine)
Phencyclidine is a dissociative anesthetic and one of the original federal "SAMHSA-5" analytes. Modern programs continue to include it under DOT and federal gui
depressantBenzodiazepines
Benzodiazepines are a family of prescription CNS depressants. They appear on 10-panel and many expanded clinical panels, but immunoassay sensitivity varies wide
depressantBarbiturates
Barbiturates are an older class of CNS depressants. Their use in routine medicine is now limited, but they remain on 10-panel screens and many recovery-monitori
opioidMethadone
Methadone is a long-acting synthetic opioid used for chronic pain and as opioid-use-disorder treatment. It is not detected by standard "opiates" immunoassays an
opioidFentanyl
Fentanyl is a potent synthetic opioid. SAMHSA added fentanyl and its metabolite norfentanyl to the federal urine and oral-fluid panels effective July 7, 2025, r
alcoholAlcohol (ethanol)
Workplace alcohol testing is typically a breath test (BrAC) under DOT and most non-DOT programs. EtG and EtS are conjugated metabolites measurable in urine for